Pipeline: Soft Tissue Reconstruction

EXPLORING POTENTIAL APPLICATION IN SOFT TISSUE RECONSTRUCTION

Acute full-thickness skin defects that require soft tissue reconstruction can include traumatic wounds such as abrasions and degloving, which is a type of injury where the skin is removed from the underlying tissue.

Skin grafting is the standard of care for full-thickness, soft tissue reconstruction. In 2017 approximately 80% of acute wounds that required skin grafting were non-burn related injuries accounting for more than 200,000 procedures in the U.S. [1]

Investigational research with the RECELL® System for the treatment of soft tissue reconstruction persists in the medical community. For general information about our science and technology, please contact our Medical Affairs team.

Click here for more information about eligibility and enrollment in AVITA Medical’s Soft Tissue Clinical Study.

ADDITIONAL RESEARCH: Abstracts, Posters, Publications

  • POSTER: Bush. Design of a Prospective Multicenter Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of Autologous Skin Cell Suspension Combined with Meshed Autograft for Reduction of Donor Area in Soft Tissue Reconstruction. Boswick Burn and Wound Care Symposium. 2020 January 26-30; Maui, HI.
  • PRESENTATION: Quick. Design of a Prospective Multicenter Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of Autologous Skin Cell Suspension Combined with Meshed Autograft for Reduction of Donor Area in Soft Tissue Reconstruction. North American Burn Society. 2020.
  • PRESENTATION: K. Foster. Compassionate Use of an Autologous Skin Cell Suspension in a Patient with a Large Soft Tissue Defect Due to a Necrotizing Soft Tissue Infection. Boswick Burn and Wound Care Symposium. 2019.
  • POSTER: I. Smith. Use of regenerative skin suspension in the treatment of complex de-gloving injury. Wounds UK. 2017.
  • Hammer et. al. J Tissue Eng Regen Med. Restoring full-thickness defects with spray skin in conjunction with dermal regenerative template and split-thickness skin grafting: a pilot study. 2017 Dec;11(12):3523-3529
    https://pubmed.ncbi.nlm.nih.gov/28326683/
  • Valerio et. al. Plast Reconstr Surg Glob. A case report of the first nonburn-related military trauma victim treated with spray skin regenerative therapy in combination with a dermal regenerate template. 2016;4:e1174
  • POSTER: Manton. Treatment of Pretibial Laceration in the Outpatient Department with Autologous Non-Cultured Cell Therapy. European Wound Management Association (EWMA). 2016.
  • POSTER: Rendon. Restoration of Full Thickness Soft Tissue Defects with Spray Skin Epidermal Regenerative Technology in Conjunction with Dermal Regenerate. Plastic Surgery. 2015.
  • POSTER: Hammer. Restorative Spray Skin Technology and Reduction of Skin Graft Donor Site Burden: A Comparative Pilot Study. Military Health System Research Symposium (MHSRS). 2015.
  • POSTER: Fleming. Regeneration of a Full Thickness Soft Tissue Defect with Autologous Spray Skin Epidermal Regenerative Technology in Conjunction with a Dermal Regenerate Template and Widened Meshed STSG. US National Capital Region Research Competition. 2015
  • https://pubmed.ncbi.nlm.nih.gov/28293522/
  • O’Neill et. al. Burns. Complex chemical burns following a mass casualty chemical plant incident: how optimal planning and organisation can make a difference. 2012;38(5):713-8
    https://pubmed.ncbi.nlm.nih.gov/22356814/

Caution: The use of RECELL® as an adjunct to meshed autografts in patients undergoing reconstruction of skin defects not associated with a burn injury is limited by U.S. law to investigational use.

The RECELL® System is approved by the U.S. Food and Drug Administration (FDA) for the treatment of acute thermal burns in patients 18 years and older. Click here for Important Safety Information and Instructions for Use.


  1. © Procedural Data 2017 Millennium Research Group, transmission or publication is prohibited. Reprinted with permission. Millennium Research Group, Inc. (“MRG”) makes no representation or warranty as to the accuracy or completeness of the data (“MRG Materials”) set forth herein and shall have, and accept, no liability of any kind, whether in contract, tort (including negligence) or otherwise, to any third party arising from or related to use of the MRG Materials by Customer. Any use which Customer or a third party makes of the MRG Materials, or any reliance on it, or decisions to be made based on it, are the sole responsibilities of Customer and such third party. In no way shall any data appearing in the MRG Materials amount to any form of prediction of future events or circumstances and no such reliance may be inferred or implied.
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