Avita Medical is working with leading researchers and institutions in the field  of regenerative medicine and has more than 60 papers published in peer reviewed journals. Below is a selection of publications, to download the full bibliography please click here.


A randomized trial comparing ReCell® system of epidermal cells delivery versus classic skin grafts for the treatment of deep partial thickness burns.

2-cohort RCT (n=82). Use of RES for effective healing with reduced donor area and less postoperative pain (p=0.03) were observed vs skin grafting.

A prospective randomised clinical pilot study to compare the effectiveness of Biobrane® synthetic wound dressing, with or without autologous cell suspension, to the local standard treatment regimen in paediatric scald injuries.

3-cohort pilot RCT (n=13). Early intervention with Biobrane® + RES was associated with effective healing (without grafting), less pain and better scar outcomes. Used within 4 days of injury, saved on nursing time, dressing, analgesic and scar management costs.

References

  1. Zajicek R, Padcuga I, Suca H, Konigova R, Broz L, Matouskova E. Healing of widely mesh autografts using freshly isolated autologous epidermal cells and acellular Xe-Derma xenodermis. Healing Wounds 2012; 6(2):12-18.
  2. O’Neill TB, Rawlins J, Rea S, Wood F. Complex chemical burns following a mass casualty chemical plant incident: How optimal planning and organization can make a difference. Burns 2012; 38:713-718.
  3. Holmes JH. Compassionate use of ReCell® in a massive burn injury. Presented at: The 17th Congress of the International Society for Burn Injuries; 2014 Oct 12-16; Sydney, Australia.
  4. Foster K, Richey K, Pressman M, Caruso D. Compassionate use of ReCell® and meshed autografts in three patients with extensive burn injury. Presented at: The 47th Annual Meeting of the American Burn Association; 2015 Apr 21-24; Chicago, USA.
  5. Wood F, Martin L, Lewis D, Rawlins J, McWilliams T, Burrow S, Rea S. A prospective randomized clinical pilot study to compare the effectiveness of Biobrane® synthetic wound dressing, with or without autologous cell suspension, to the local standard treatment regimen in paediatric scald injuries. Burns 2012; 38:830-839.
  6. Dunne JA, Rawlins JM. Early paediatric scald surgery – a cost effective dermal preserving surgical protocol for all childhood scalds. Burns 2014; 40:772-783.
  7. Valerio, IL. Composite Tissue Reconstruction, Cranio-facial Reconstruction, Abdominal Wall and Regenerative Medicine in Combat Casualty Care. 8th Congress of World Society for Reconstructive Microsurgery, March 2015, Mumbai, India.
  8. Lim J, Liew S, Chan H, Jackson T, Burrows S, Edgar DW, Wood FM. Is the length of time in acute burn surgery associated with poorer outcomes? Burns 2014; 40:235-240.
  9. Urr R, Carter JE, Molnar JA, Holmes JH. Compassionate use of ReCell® in a massive burn injury. Presented at: The 27th Annual Southern Region Burn Conference; 2014 Nov 14-16; Houston, USA.
  10. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975; 6(3):331-343.
  11.  Green H, Rheinwald JG, Sun T. Properties of an epithelial cell type in culture: the epidermal keratinocyte and its dependence on products of the fibroblast. Progress in Clinical and Biological research, 1977; 17:493-500.
  12. Singer AJ, Clark RAF. Cutaneous wound healing. New England Journal of Medicine 1999;341(10):738-746.
  13. Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, Patel SB, Khalid L, Isseroff RR, Tomic-Canic M. Epithelialization in wound healing: A comprehensive review. Advances in Wound Care 2014; 3(7):445-464. ):738-746.
  14. Mayor R, Caroma-Fontaine C. Keeping in touch with contact inhibition of locomotion.
    2010. Trends in Cell Biology. 20(6) 319-328.
  15. Grinnell F. Fibroblasts, myofibroblasts and wound contraction. J Cell Biol. 1994 124(4):401-404.
  16. Sorrell JM, Caplan AI. Fibroblast heterogeneity: more than skin deep. J Cell Sci. 2004;117(Pt 5):667–675.
  17. Hirobe T. Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Pigment Cell Research 2004; 8:2-12.
  18. Yamaguchi Y, Brenner M, Hearing VJ. The regulation of skin pigmentation. Journal of Biological Chemistry 2007; 282(38): 27557-27561.
  19. Wood FM, Giles N, Stevenson A, Rea S, Fear M. Characterisation of the cell suspension harvested from the dermal epidermal junction
  20. Rebowe R, Williams J, Craig C, Carter J, Molnar J, Holmes J. Compassionate use of ReCell® in the treatment of large burns: a
    single center experience. Presented at: The 28th Annual ABA Southern Region Burn Conference, 2015 Nov 20-22; Dallas, Texas, USA.
  21. Lyons J, Kagan R. The true meshing ratio of skin graft meshers. Journal of Burn Care and Research 2014; 35: 257-2260v.using a ReCell® kit. Burns 2012; 38:44-51.