Better outcomes in burns than mesh grafting alone

ReCell® is a medical device that has been used to treat thousands of patients worldwide. ReCell® can be used in conjunction with conventional treatments such as mesh grafting for burns and reconstructive procedures.

ReCell®’s unique proprietary technology enables a clinician to rapidly create RES™ – Regenerative Epithelial Suspension – using just a small sample of the patient’s skin.

The disaggregated cells in RES™ are no longer contact-inhibited12 and therefore behave like those at an acute wound’s edge. RES™ introduces the cell signalling associated with wound healing across the surface area of the wound.

RES™ contains the multiple skin cell phenotypes and normal wound healing factors19 that are necessary for the restoration of normal skin functionality and appearance.10

Advantages of ReCell®

ReCell® offers distinct advantages in the treatment of wounds caused by burns:

Definitive Closure with Less Donor Skin

  • Faster epithelialisation of widely-meshed skin graft interstices1,2 decreasing donor skin requirements in mixed depth injuries3,4,9
  • Smaller donor sites: just 1/80th of the treatment area5,6
  • Well suited for extensive burn injuries, where donor skin is in short supply
  • Each device can treat wounds up to 1920 cm2 * in size.

Health Economic Benefits

  • Reduced follow-on reconstructive procedures7
  • Reduced requirement for scar management5
  • Reduced number of surgical interventions8

Superior Outcomes

  • Regenerated skin has a superior appearance compared with meshed autograft alone4
  • Regenerated skin exhibits more normal collagen formation4,7

* Please enquire on availability in your country.

ReCell® Product Video

Regenerative Epithelial Suspension – RES™

The regenerative mechanism is within the suspension

Avita Medical’s range regenerative devices are used by clinicians to prepare RES™ – Regenerative Epithelial Suspension™. RES™ is an autologous suspension composed of the cells and wound-healing factors necessary to regenerate natural, healthy skin.

How RES™ repairs burns and acute wounds:

Effective healing and the formation of good quality skin requires the presence and products of keratinocytes, fibroblasts and melanocytes.10-14 RES™ contains viable populations of all these skin cell phenotypes and enables earlier definitive closure by replacing all of these across the whole wound. This enables healing across the surface of the wound rather than just from the edges and dermal appendages.13-15 These cells are highly interactive and communicate with each other via secreted factors, their receptors and via cell/cell contacts resulting in the regeneration of normal, pigmented skin.12,16-18

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References
  1. Zajicek R, Padcuga I, Suca H, Konigova R, Broz L, Matouskova E. Healing of widely mesh autografts using freshly isolated autologous epidermal cells and acellular Xe-Derma xenodermis. Healing Wounds 2012; 6(2):12-18.
  2. O’Neill TB, Rawlins J, Rea S, Wood F. Complex chemical burns following a mass casualty chemical plant incident: How optimal planning and organization can make a difference. Burns 2012; 38:713-718.
  3. Holmes JH. Compassionate use of ReCell® in a massive burn injury. Presented at: The 17th Congress of the International Society for Burn Injuries; 2014 Oct 12-16; Sydney, Australia.
  4. Foster K, Richey K, Pressman M, Caruso D. Compassionate use of ReCell® and meshed autografts in three patients with extensive burn injury. Presented at: The 47th Annual Meeting of the American Burn Association; 2015 Apr 21-24; Chicago, USA.
  5. Wood F, Martin L, Lewis D, Rawlins J, McWilliams T, Burrow S, Rea S. A prospective randomized clinical pilot study to compare the effectiveness of Biobrane® synthetic wound dressing, with or without autologous cell suspension, to the local standard treatment regimen in paediatric scald injuries. Burns 2012; 38:830-839.
  6. Dunne JA, Rawlins JM. Early paediatric scald surgery – a cost effective dermal preserving surgical protocol for all childhood scalds. Burns 2014; 40:772-783.
  7. Valerio, IL. Composite Tissue Reconstruction, Cranio-facial Reconstruction, Abdominal Wall and Regenerative Medicine in Combat Casualty Care. 8th Congress of World Society for Reconstructive Microsurgery, March 2015, Mumbai, India.
  8. Lim J, Liew S, Chan H, Jackson T, Burrows S, Edgar DW, Wood FM. Is the length of time in acute burn surgery associated with poorer outcomes? Burns 2014; 40:235-240.
  9. Urr R, Carter JE, Molnar JA, Holmes JH. Compassionate use of ReCell® in a massive burn injury. Presented at: The 27th Annual Southern Region Burn Conference; 2014 Nov 14-16; Houston, USA.
  10. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975; 6(3):331-343.
  11. Green H, Rheinwald JG, Sun T. Properties of an epithelial cell type in culture: the epidermal keratinocyte and its dependence on products of the fibroblast. Progress in Clinical and Biological research, 1977; 17:493-500.
  12. Singer AJ, Clark RAF. Cutaneous wound healing. New England Journal of Medicine 1999;341(10):738-746.
  13. Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, Patel SB, Khalid L, Isseroff RR, Tomic-Canic M. Epithelialization in wound healing: A comprehensive review. Advances in Wound Care 2014; 3(7):445-464. ):738-746.
  14. Mayor R, Caroma-Fontaine C. Keeping in touch with contact inhibition of locomotion.
    2010. Trends in Cell Biology. 20(6) 319-328.
  15. Grinnell F. Fibroblasts, myofibroblasts and wound contraction. J Cell Biol. 1994 124(4):401-404.
  16. Sorrell JM, Caplan AI. Fibroblast heterogeneity: more than skin deep. J Cell Sci. 2004;117(Pt 5):667–675.
  17. Hirobe T. Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Pigment Cell Research 2004; 8:2-12.
  18. Yamaguchi Y, Brenner M, Hearing VJ. The regulation of skin pigmentation. Journal of Biological Chemistry 2007; 282(38): 27557-27561.
    19.Wood FM, Giles N, Stevenson A, Rea S, Fear M. Characterisation of the cell suspension harvested from the dermal epidermal junction
  19. Rebowe R, Williams J, Craig C, Carter J, Molnar J, Holmes J. Compassionate use of ReCell® in the treatment of large burns: a
    single center experience. Presented at: The 28th Annual ABA Southern Region Burn Conference, 2015 Nov 20-22; Dallas, Texas, USA.
  20. Lyons J, Kagan R. The true meshing ratio of skin graft meshers. Journal of Burn Care and Research 2014; 35: 257-2260v.using a ReCell® kit. Burns 2012; 38:44-51.