Regenerative Epithelial Suspension™ – RES™ – is an autologous suspension composed of the cells and wound-healing factors necessary to regenerate natural healthy skin.
Avita’s unique regenerative technology enables clinicians to rapidly create and apply RES™ at the point of care in a simple 30-minute procedure.
Activated – Disaggregation of skin cells removes contact inhibition, known as the “free edge” effect, which initiates a cascade of wound healing cell signals 1,2. Growth factors and cytokines are rapidly secreted by “free edge” keratinocytes and fibroblasts 1-6. This triggers a cascade of processes vital for skin regeneration: proliferation, migration, angiogenesis and matrix re-modelling 7.
Available – RES™ is produced immediately within minutes at the point of care and delivers non-cultured disaggregated skin cells 8,9 across the surface of the wound, overcoming the usual limitations of the wound edge 2, 9.
Autologous – The patient is the donor: RES™ is safe as it is generated from the patient’s own skin. In addition, there is no risk of graft failure due to rejection.11-13
Complete – The multi-phenotype skin cells contained in RES™ 7 are essential in the normal cellular processes for effective wound healing and complete restoration of normal functionality, such as durability, pigmentation, minimal contracture. 4, 14-17 Application of fibroblasts and keratinocytes overcomes the usual limitation of availability of healthy cells and regenerates normal skin, avoiding the body’s mechanism for emergency closure by contraction. 1,2, 4, 16, 17 Melanocytes contained in RES™ 8 survive to localize to the epidermal side of the dermal-epidermal junction and evenly distribute melanin 14,15 throughout the epidermis for normal pigmentation of the new skin.18