Regenerative Epithelial Suspension™ – RES™ – is an autologous suspension composed of the cells and wound-healing factors necessary to regenerate natural healthy skin.
Avita’s unique regenerative technology enables clinicians to rapidly create and apply RES™ at the point of care in a simple 30-minute procedure.
Activated – Disaggregation of skin cells removes contact inhibition, inducing the “free edge” effect2 which initiates a cascade of wound healing cell signals.14
Growth factors and cytokines are rapidly secreted by “free edge” keratinocytes and fibroblasts to orchestrate proliferation, migration, angiogenesis and matrix re-modelling processes which are essential for skin regeneration.3-13
In laboratory experiments, RES™ has been shown to exhibit the characteristics of cells in the “free edge” state. Investigators found that large numbers of viable cells from RES™ adhere to a wound bed almost instantly and displayed typical proliferative and migratory morphologies as early as day 1 post-harvest. Key proteins (Involucrin and P-ERK) associated with activation were shown to increase and decrease, in accordance with the literature.14
Available – RES™ is available within minutes at the point of care and delivers non-cultured disaggregated skin cells which trigger signalling across the surface of the wound, overcoming the usual limitations of the wound edge.1,15-19
Autologous – The patient is the donor: RES™ is produced from the patient’s skin. In addition, there is no risk of an adverse immune response.20
Complete – The multi-phenotype skin cells1 contained in RES™ are essential in the normal cellular processes for effective wound healing and restoration of normal functionality (e.g. durability, pigmentation, minimal contracture).21
Melanocytes contained in RES™ survive to localize to the epidermal side of the dermal-epidermal junction and evenly distribute melanin throughout the epidermis for pigmentation of the new skin.22
Application of RES™ increases the number of resident fibroblasts in the wound to reduce migration and wound tension,23-25 which reduces the incidence of contracture.