What is RES™?

Regenerative Epithelial Suspension™ – RES™ – is an autologous suspension composed of the cells and wound-healing factors necessary to regenerate natural healthy skin.

Avita’s unique regenerative technology enables clinicians to rapidly create and apply RES™ at the point of care in a simple 30-minute procedure.

The regenerative mechanism is within the suspension…

Activated – Disaggregation of skin cells removes contact inhibition, known as the “free edge” effect, which initiates a cascade of wound healing cell signals 1,2. Growth factors and cytokines are rapidly secreted by “free edge” keratinocytes and fibroblasts 1-6. This triggers a cascade of processes vital for skin regeneration: proliferation, migration, angiogenesis and matrix re-modelling 7.

Available – RES™ is produced immediately within minutes at the point of care and delivers non-cultured disaggregated skin cells 8,9 across the surface of the wound, overcoming the usual limitations of the wound edge 2, 9.

Autologous – The patient is the donor: RES™ is safe as it is generated from the patient’s own skin. In addition, there is no risk of graft failure due to rejection.11-13

Complete – The multi-phenotype skin cells contained in RES™ 7 are essential in the normal cellular processes for effective wound healing and complete restoration of normal functionality, such as durability, pigmentation, minimal contracture. 4, 14-17 Application of fibroblasts and keratinocytes overcomes the usual limitation of availability of healthy cells and regenerates normal skin, avoiding the body’s mechanism for emergency closure by contraction. 1,2, 4, 16, 17 Melanocytes contained in RES™ 8 survive to localize to the epidermal side of the dermal-epidermal junction and evenly distribute melanin 14,15 throughout the epidermis for normal pigmentation of the new skin.18

Simple. Safe. Effective.

  • A single use medical device

  • Used at the point of care

  • Prepares RES™ in as little as 30 minutes


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  2. Singer AJ, Clark RAF. Cutaneous wound healing. New England Journal of Medicine 1999;341(10):738-746
  3. Green H, Rheinwald JG, Sun T. Properties of an epithelial cell type in culture: the epidermal keratinocyte and its dependence on products of the fibroblast. Progress in Clinical and Biological research, 1977; 17:493-500.
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  5. Dunnill, C. and Georgopoulos, N.  Personal communication 2016 University of Huddersfield
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  8. Wood FM, Giles N, Stevenson A, Rea S, ZFear M. Characterisation of the cell suspension harvested from the dermal epidermal junction using a ReCell® kit. Burns 2012; 38:44-51
  9. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975; 6(3):331-343.
  10. Velander P, Theopold C, Bleiziffer O, Bergmann J, Svensson H, Yao F, Eriksson E. Cell suspensions of autologous keratinocytes or autologous fibroblasts accelerate the healing of full thickness skin wounds in a diabetic porcine wound healing model. Journal of Surgical Research 2009; 157:14-20
  11. Billingham RE, Medawar PB. The technique of free skin grafting in mammals. Journal of Experimental Biology 1951; 385-402.
  12. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1953; 172(4379):603-606.
  13. Benichou G, Yamada Y, Yun S, Lin C, Fray M, Tocco G. Immune recognition and rejection of allogeneic skin grafts. Immunotherapy 2011; 3(6):757-770
  14. Hirobe T. Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Pigment Cell Research 2004; 18:2-12.
  15. Yamaguchi Y, Brenner M, Hearing VJ. The regulation of skin pigmentation. Journal of Biological Chemistry 2007; 282(38):27557-27561
  16. Sorrell JM, Caplan AI. Fibroblast heterogeneity: more than skin deep. J Cell Sci. 2004;117(Pt 5):667–675
  17. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994, 124(4): 401-404
  18. Navarro FA, Stoner ML, Lee HB, Park CS, Wood FM, Orgill DP. Melanocyte repopulation in full-thickness wounds using a cell spray apparatus. Journal of Burn Care and Research 2000 ; 22(1):41-46