Scars occur when the edges of a wound cannot quickly join. The healing process focuses on closing the gap quickly more than producing good quality skin. By restoring a normal epidermis (the top layer of the skin), RES™ enables the normalisation of the cellular activity underneath that ultimately improves the overall skin structure. It has to be remembered that once established, a scar can never be completely removed, it can only be remodelled so it blends with the surrounding tissue and is less noticeable. Not every scar can benefit from ReNovaCell™ and your clinician will be able to advise on the best course of action.
Hypopigmentation disorders, such as vitiligo, result in patches of abnormally white skin and are the result of a lack of pigmentation (melanin) which is produced by cells called melanocytes. There are many different reasons why these cells stop producing melanin.
Melanocytes can be transplanted from an area of “normal” colour to an area of hypopigmentation. If transplanted at the same proportion as normal skin, the resulting skin can be the same colour as the surrounding skin, providing that the underlying cause that caused the damage to the melanocytes is under control.
Many cosmetic procedures involve the removal of the top layer of skin blotches and other skin imperfections. Such procedures, including laser resurfacing, deep peels and dermabrasion, can result in significant redness for prolonged periods of time and are at risk of scar formation.
Clinicians may recommend the use of ReNovaCell™ to reduce the amount of swelling and redness after an operation and to reduce the risk of scar formation. The application of colour skin cells (melanocytes) may also result in more normal coloured skin.
A skin sample is a thin small shave of skin, usually taken from a discreet area of the body.
The sample is used to gather the cells that will be used to treat the skin. The sample is taken from an area of natural healthy skin. The size of the sample can be up to the size and thickness of several postage stamps.
The donor site is the area from which a sample is taken.
During the procedure your clinician will also apply RES™ to the donor site to ensure that this area heals properly.
Melanocytes are the cells that produce skin colour (melanin). Viable Melanocytes are one of the cellular constituents of RES™. Melanocytes will progressively deposit melanin over several months and the pigmentation will gradually return.
ReNovaCell™ is unique. It uses the regenerative capabilities of your own cells to minimise scaring risk and improve skin texture and restore pigmentation. It doesn’t require sophisticated instruments and the clinician can prepare the RES™ at the bed side in about 30 minutes. Only a very small skin sample is needed and no adverse event specific to the use of ReNovaCell™ are to be anticipated as your own cells are being used.
This generally occurs in a consultation room. A small sample of skin is collected skin. The donor site is usually around one to two centimetres square (the size and thickness of several postage stamps) and is also treated with the spray to help it heal properly.
While the clinician is preparing the area to be treated by removing the top layers of skin, the healthy skin sample is placed into the ReNovaCell™ device. ReNovaCell™ separates the cells into a suspension allowing the clinician to spray it onto the wound. The healthy cells are applied to the wound where they grow and reconstruct a skin that matches the surrounding tissue in terms of texture and colour.
After the procedure the treated area and donor site will be covered with a dressing. The area will initially be numb but may sting soon after the operation. This is normal and you are usually allowed to take medication to reduce any discomfort.
You should inform any healthcare professional who is looking after you and your wound that you have been treated with ReNovaCell™.
After about a week (depending on the reason why you had ReNovaCell™) the dressing will be removed by your clinician. Your clinician will give you advice concerning what creams you are allowed to use, how much you can expose the treated area to the sun and what you should expect after the treatment.
If you have had the treatment to reintroduce pigment (e.g. vitiligo), the re-pigmentation will occur slowly over several months as the cells grow, mature and start to produce pigment (melanin). Your clinician will be able to advise you how long it will take for re-pigmentation to occur.
Following treatment, the treated area will change over a period of weeks and months. The pigmentation (skin colour) and surface scarring will continue to mature and improve over the next 12-18 months. The final result of the ReNovaCell™ treatment is permanent.
ReNovaCell™ is a very safe procedure as it uses your own cells, so no specific risks are related to the procedure. After removal of all the dressings, the skin will be red and there may be some scabs. This is normal. Your clinician will give you advice concerning what creams you are allowed to use and what you should expect after the treatment.
As with any treatment, there are risks associated with ReNovaCell™ treatment. For example, you may have a reaction to the anaesthesia or you may get an infection that result in you requiring antibiotics, undergoing more treatment or getting scars. It is important that you discuss all possible outcomes with your clinician before consenting to any operation so that you are aware of all potential side effects and complications.
ReNovaCell™ should not be used on infected wounds. Patients with a known hypersensitivity (allergy) to anaesthesia, sodium lactate or the enzyme (Trypsin) should not be treated using ReNovaCell™.
It is also important that the patient is willing to comply with post-operative instructions to avoid the risk of complications.