ReNovaCell’s® unique proprietary technology enables a clinician to rapidly create RES™ – Regenerative Epithelial Suspension – using just a small sample of the patient’s skin.
The physiologically relevant and complete nature of RES™ underpins its potential for restoration of normal skin characteristics.
Activated – Disaggregation of skin cells removes contact inhibition, known as the “free edge” effect, which initiates a cascade of wound healing cell signals. Growth factors and cytokines are rapidly secreted by “free edge” keratinocytes and fibroblasts to orchestrate proliferation, migration, angiogenesis and matrix re-modelling processes which are essential for skin regeneration.
Available – Normal skin regeneration requires multiple skin types and processes. The use of RES™ introduces disaggregated epithelial cells and the associated signalling across the surface of the wound, overcoming the usual limitations of the wound edge (Figure 1).
Autologous – RES™ is safe as it is generated from the patient’s own skin. In addition, there is no risk of graft failure due to rejection.
Complete – The multi-phenotype skin cells1 contained in RES™ are essential in the normal cellular processes for effective wound healing and complete restoration of normal functionality (e.g. durability, pigmentation, minimal contracture). Melanocytes contained in RES™ survive to localize to the epidermal side of the dermal-epidermal junction and evenly distribute melanin throughout the epidermis for normal pigmentation of the new skin.